We study the presence and the physiological and pathological roles of G-quadruplexes and i-Motifs in several viruses (e.g. HIV, HSV, arboviruses), bacteria (Mycobacterium), cancers (liposarcoma) and neurodegenerative diseases (X-linked dystonia parkinsonism) .

We apply techniques in vitro (circular dichroism, fluorescence resonance energy transfer, Taq polymerase stop assay) and in cells (pull-down coupled with mass spectrometry, immunofluorescence, proximity ligation assay, FISH), including genome-wide techniques such as ChIP-seq, CUT&Tag, RNA-seq.